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Index > Protein center > GDI1(Gene name) > Human
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  • GDI1 (Gene name),
  • Rab GDP dissociation inhibitor alpha (Protein name ),  GDIA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GDI1(GDIL;OPHN2;RABGDIA;XAP4);
    Protein name:
    Rab GDP dissociation inhibitor alpha(Rab GDI alpha);
    Alternative:
    Oligophrenin-2;Guanosine diphosphate dissociation inhibitor 1(GDI-1);Protein XAP-4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RHOH.
    Function:
    Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    447
    Sequence:
    50:
    MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE | 
    100:
    ELYKRFQLLE | GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL | 
    150:
    DFKVVEGSFV | YKGGKIYKVP | STETEALASN | LMGMFEKRRF | RKFLVFVANF | 
    200:
    DENDPKTFEG | VDPQTTSMRD | VYRKFDLGQD | VIDFTGHALA | LYRTDDYLDQ | 
    250:
    PCLETVNRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR | LSAIYGGTYM | 
    300:
    LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VRKAGQVIRI | 
    350:
    ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI | 
    400:
    AIASTTVETT | DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGCESQVFC | 
    447:
    SCSYDATTHF | ETTCNDIKDI | YKRMAGTAFD | FENMKRKQND | VFGEAEQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    UniGene:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Rab GDI alpha
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    ELISA Kit for Human Rab GDI alpha
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    ELISA Kit for Human Rab GDI alpha
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    ELISA Kit for Human Rab GDI alpha
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    ELISA Kit for Human Rab GDI alpha
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    E1617m
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    CLIA Kit for Human Rab GDI alpha
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    CLIA Kit for Human Rab GDI alpha
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    CLIA Kit for Human Rab GDI alpha
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    CLIA Kit for Human Rab GDI alpha
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    CLIA Kit for Human Rab GDI alpha
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    Polyclonal Antibody for Human Rab GDI alpha
    Polyclonal Antibody for Human Rab GDI alpha
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    P1617Rb-h
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    Polyclonal Antibody for Human Rab GDI alpha
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    Polyclonal Antibody for Human Rab GDI alpha
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    P1617Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Rab GDI alpha
    Monoclonal Antibody for Human Rab GDI alpha
    Monoclonal Antibody for Human Rab GDI alpha
    Monoclonal Antibody for Human Rab GDI alpha
    Monoclonal Antibody for Human Rab GDI alpha
    Monoclonal Antibody for Human Rab GDI alpha
    Protein for Human Rab GDI alpha
    Protein for Human Rab GDI alpha
    Protein for Human Rab GDI alpha
    Protein for Human Rab GDI alpha
    Protein for Human Rab GDI alpha

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI)."
      Sedlacek Z. , Konecki D.S. , Korn B. , Klauck S.M. , Poustka A.
      Mamm. Genome5:633-639(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens."
      Nishimura N. , Goji J. , Nakamura H. , Orita S. , Takai Y. , Sano K.
      Cancer Res.55:5445-5450(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Retina.
    3. 3.
      "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
      Chen E.Y. , Zollo M. , Mazzarella R.A. , Ciccodicola A. , Chen C.-N. , Zuo L. , Heiner C. , Burough F.W. , Ripetto M. , Schlessinger D. , D'Urso M.
      Hum. Mol. Genet.5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    4. 4.
      Feng Z. , Zhang B. , Zhou Y. , Peng X. , Yuan J. , Qiang B.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees."
      Kitano T. , Schwarz C. , Nickel B. , Paeaebo S.
      Mol. Biol. Evol.20:1281-1289(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
    11. 11.
      "Rapid identification of gene sequences for transcriptional map assembly by direct cDNA screening of genomic reference libraries."
      Hochgeschwender U.
      Submitted (1994-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-181
    12. 12.
      Lubec G. , Vishwanath V.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 143-156; 174-193 AND 222-240;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
    13. 13.
      Bhat K.S.
      Submitted (1992-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 328-436
    14. 14.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 349-361
      tissue: Keratinocyte.
    15. 15.
      "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport."
      Bachner D. , Sedlacek Z. , Korn B. , Hameister H. , Poustka A.
      Hum. Mol. Genet.4:701-708(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    16. 16.
      "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function."
      Li X. , Bu X. , Lu B. , Avraham H. , Flavell R.A. , Lim B.
      Mol. Cell. Biol.22:1158-1171(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHOH
    17. 17.
      "GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation."
      Chen Y. , Deng Y. , Zhang J. , Yang L. , Xie X. , Xu T.
      Biochem. J.422:229-235(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB10;SUBCELLULAR LOCATION
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy."
      Kirsten M.L. , Baron R.A. , Seabra M.C. , Ces O.
      Mol. Membr. Biol.30:303-314(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB1A AND RAB5A;FUNCTION
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MRX41 PRO-92
    21. 21.
      "Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor."
      Bienvenu T. , Des Portes V. , Saint Martin A. , McDonell N. , Billuart P. , Carrie A. , Vinet M.-C. , Couvert P. , Toniolo D. , Ropers H.-H. , Moraine C. , van Bokhoven H. , Fryns J.-P. , Kahn A. , Beldjord C. , Chelly J.
      Hum. Mol. Genet.7:1311-1315(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MRX41 PRO-423
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