Gene name:
GDI1 (GDIL;OPHN2;RABGDIA;XAP4) ;
Protein name:
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) ;
Alternative:
Oligophrenin-2 ;Guanosine diphosphate dissociation inhibitor 1 (GDI-1) ;Protein XAP-4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RHOH.
Function:
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MDEEYDVIVL | GTGLTECILS | GIMSVNGKKV | LHMDRNPYYG | GESSSITPLE |
100:
ELYKRFQLLE | GPPESMGRGR | DWNVDLIPKF | LMANGQLVKM | LLYTEVTRYL |
150:
DFKVVEGSFV | YKGGKIYKVP | STETEALASN | LMGMFEKRRF | RKFLVFVANF |
200:
DENDPKTFEG | VDPQTTSMRD | VYRKFDLGQD | VIDFTGHALA | LYRTDDYLDQ |
250:
PCLETVNRIK | LYSESLARYG | KSPYLYPLYG | LGELPQGFAR | LSAIYGGTYM |
300:
LNKPVDDIIM | ENGKVVGVKS | EGEVARCKQL | ICDPSYIPDR | VRKAGQVIRI |
350:
ICILSHPIKN | TNDANSCQII | IPQNQVNRKS | DIYVCMISYA | HNVAAQGKYI |
400:
AIASTTVETT | DPEKEVEPAL | ELLEPIDQKF | VAISDLYEPI | DDGCESQVFC |
447:
SCSYDATTHF | ETTCNDIKDI | YKRMAGTAFD | FENMKRKQND | VFGEAEQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Rat
Dog
Mouse
ELISA Kit for Human Rab GDI alpha
ELISA Kit for Human Rab GDI alpha
ELISA Kit for Human Rab GDI alpha
ELISA Kit for Human Rab GDI alpha
ELISA Kit for Human Rab GDI alpha
CLIA Kit for Human Rab GDI alpha
CLIA Kit for Human Rab GDI alpha
CLIA Kit for Human Rab GDI alpha
CLIA Kit for Human Rab GDI alpha
CLIA Kit for Human Rab GDI alpha
Polyclonal Antibody for Human Rab GDI alpha
Polyclonal Antibody for Human Rab GDI alpha
Polyclonal Antibody for Human Rab GDI alpha
Polyclonal Antibody for Human Rab GDI alpha
Polyclonal Antibody for Human Rab GDI alpha
Monoclonal Antibody for Human Rab GDI alpha
Monoclonal Antibody for Human Rab GDI alpha
Monoclonal Antibody for Human Rab GDI alpha
Monoclonal Antibody for Human Rab GDI alpha
Monoclonal Antibody for Human Rab GDI alpha
Protein for Human Rab GDI alpha
Protein for Human Rab GDI alpha
Protein for Human Rab GDI alpha
Protein for Human Rab GDI alpha
Protein for Human Rab GDI alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Retina .
3.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
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Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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more...
Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
Mural R.J.
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Myers E.W.
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Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Lung .
11.
"Rapid identification of gene sequences for transcriptional map assembly by direct cDNA screening of genomic reference libraries."
Hochgeschwender U.
Submitted (1994-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-181
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 143-156; 174-193 AND 222-240;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
13.
Bhat K.S.
Submitted (1992-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 328-436
14.
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Cited for : PROTEIN SEQUENCE OF 349-361
tissue :
Keratinocyte .
15.
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Cited for : TISSUE SPECIFICITY
16.
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Cited for : INTERACTION WITH RHOH
17.
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Cited for : INTERACTION WITH RAB10;SUBCELLULAR LOCATION
18.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
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Cited for : INTERACTION WITH RAB1A AND RAB5A;FUNCTION
20.
"Mutations in GDI1 are responsible for X-linked non-specific mental retardation."
D'Adamo P.
,
Menegon A.
,
Lo Nigro C.
,
Grasso M.
,
Gulisano M.
,
Tamanini F.
,
Bienvenu T.
,
Gedeon A.K.
,
Oostra B.
,
Wu S.-K.
,
Tandon A.
,
Valtorta F.
,
Balch W.E.
,
Chelly J.
,
Toniolo D.
Nat. Genet.19:134-139(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT MRX41 PRO-92
21.
"Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor."
Bienvenu T.
,
Des Portes V.
,
Saint Martin A.
,
McDonell N.
,
Billuart P.
,
Carrie A.
,
Vinet M.-C.
,
Couvert P.
,
Toniolo D.
,
Ropers H.-H.
,
Moraine C.
,
van Bokhoven H.
,
Fryns J.-P.
,
Kahn A.
,
Beldjord C.
,
Chelly J.
Hum. Mol. Genet.7:1311-1315(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT MRX41 PRO-423